Publication:
Mechanism of immunoregulatory properties of vasoactive intestinal peptide in the K/BxN mice model of autoimmune arthritis

dc.contributor.authorLeceta Martínez, Javier
dc.contributor.authorGarín, Marina I.
dc.contributor.authorConde, Carmen
dc.date.accessioned2023-06-16T14:21:42Z
dc.date.available2023-06-16T14:21:42Z
dc.date.issued2021-07-16
dc.description.abstractThe K/BxN mouse model of rheumatoid arthritis (RA) closely resembles the human disease. In this model, arthritis results from activation of autoreactive KRN T cells recognizing the glycolytic enzyme glucose-6-phosphate isomerase (GPI) autoantigen, which provides help to GPI-specific B cells, resulting in the production of pathogenic antiGPI antibodies that ultimately leads to arthritis symptoms from 4 weeks of age. Vasoactive intestinal peptide (VIP) is a neuropeptide broadly distributed in the central and peripheral nervous system that is also expressed in lymphocytes and other immune cell types. VIP is a modulator of innate and adaptive immunity, showing anti-inflammatory and immunoregulatory properties. Basically, this neuropeptide promotes a shift in the Th1/ Th2 balance and enhances dedifferentiation of T regulatory cells (Treg). It has demonstrated its therapeutic effects on the collagen-induced arthritis (CIA) mouse model of RA. In the present hypothesis and theory article, we propose that the immunoregulatory properties of VIP may be due likely to the inhibition of T cell plasticity toward non-classic Th1 cells and an enhanced follicular regulatory T cells (Tfr) activity. The consequences of these regulatory properties are the reduction of systemic pathogenic antibody titers.
dc.description.departmentDepto. de Biología Celular
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.sponsorshipInstituto de Salud Carlos III (ISCIII)/Fondo Europeo de Desarrollo Regional(FEDER)
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/71551
dc.identifier.doi10.3389/fimmu.2021.701862
dc.identifier.issn1664-3224
dc.identifier.officialurlhttps://doi.org/10.3389/fimmu.2021.701862
dc.identifier.urihttps://hdl.handle.net/20.500.14352/4818
dc.issue.number701862
dc.journal.titleFrontiers in Immunology
dc.language.isoeng
dc.page.final7
dc.page.initial1
dc.publisherFrontiers Media
dc.relation.projectID(PI17/01161, PI1701660)
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.cdu577.175.82
dc.subject.cdu616.72-002
dc.subject.keywordNeuroimmunology
dc.subject.keywordVIP
dc.subject.keywordT cell plasticity
dc.subject.keywordFollicular regulatory T cells (Tfr)
dc.subject.keywordNonclassic Th1 cells
dc.subject.ucmReumatología
dc.subject.ucmBiología molecular (Biología)
dc.subject.ucmNeurociencias (Biológicas)
dc.subject.unesco3205.09 Reumatología
dc.subject.unesco2415 Biología Molecular
dc.subject.unesco2490 Neurociencias
dc.titleMechanism of immunoregulatory properties of vasoactive intestinal peptide in the K/BxN mice model of autoimmune arthritis
dc.typejournal article
dc.volume.number12
dspace.entity.typePublication
relation.isAuthorOfPublicationb1bcb00f-fd69-4e9b-bf65-ef981b35f5ae
relation.isAuthorOfPublication.latestForDiscoveryb1bcb00f-fd69-4e9b-bf65-ef981b35f5ae
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