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Spoligotyping Profile Change Caused by Deletion of a Direct Variable Repeat in a Mycobacterium tuberculosis Isogenic Laboratory Strain

dc.contributor.authorAranaz Martín, Alicia
dc.contributor.authorRomero Martínez, Beatriz
dc.contributor.authorMontero Serra, Natalia
dc.contributor.authorÁlvarez Sánchez, Julio
dc.contributor.authorBezos Garrido, Javier
dc.contributor.authorJuan Ferré, Lucía De
dc.contributor.authorMateos García, Ana Isabel
dc.contributor.authorDomínguez Rodríguez, Lucas José
dc.date.accessioned2024-01-17T08:06:08Z
dc.date.available2024-01-17T08:06:08Z
dc.date.issued2004
dc.descriptionAutor de correspondencia: Alicia Aranaz; 2004, American Society for Microbiology. All Rights Reserved. Financiación: Ramon y Cajal Program (Spanish Ministry of Science and Technology).Pproject AGL 2001-2029 of the Spanish Ministry of Science and Technology and by the Spanish Ministry of Agriculture, Fisheries and Food (MAPA).
dc.description.abstractSpoligotyping is a major tool for molecular typing of Mycobacterium tuberculosis complex organisms. For epidemiological purposes, strains are considered clonal only when their spoligotyping patterns are identical. We report a change in the spoligotyping profiles of truly isogenic strains (a clinical isolate and a subculture derived in the laboratory) caused by deletion of a direct variable repeat. Without the information about the relationship between them, a link between these strains would have gone unnoticed. Evolutionary events should be taken into account in the interpretation of spoligotyping results and in the design of databases.
dc.description.departmentDepto. de Sanidad Animal
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia y Tecnología (España)
dc.description.sponsorshipMinisterio de Agricultura, Pesca y Alimentación (España)
dc.description.statuspub
dc.identifier.citationAranaz, A., Romero, B., Montero, N., Alvarez, J., Bezos, J., de Juan, L., Mateos, A., & Domínguez, L. (2004). Spoligotyping profile change caused by deletion of a direct variable repeat in a Mycobacterium tuberculosis isogenic laboratory strain. Journal of clinical microbiology, 42(11), 5388–5391. https://doi.org/10.1128/JCM.42.11.5388-5391.2004
dc.identifier.doi10.1128/JCM.42.11.5388-5391.2004
dc.identifier.essn1098-660X
dc.identifier.issn0095-1137
dc.identifier.officialurlhttps://doi.org/10.1128/JCM.42.11.5388-5391.2004
dc.identifier.urihttps://hdl.handle.net/20.500.14352/93502
dc.issue.number11
dc.journal.titleJournal of Clinical Microbiology
dc.language.isoeng
dc.page.final5391
dc.page.initial5388
dc.publisherAmerican Society for Microbiology
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu579.62
dc.subject.ucmMicrobiología (Veterinaria)
dc.subject.unesco3109.05 Microbiología
dc.titleSpoligotyping Profile Change Caused by Deletion of a Direct Variable Repeat in a Mycobacterium tuberculosis Isogenic Laboratory Strain
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number42
dspace.entity.typePublication
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