Spoligotyping Profile Change Caused by Deletion of a Direct Variable Repeat in a Mycobacterium tuberculosis Isogenic Laboratory Strain
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2004
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American Society for Microbiology
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Aranaz, A., Romero, B., Montero, N., Alvarez, J., Bezos, J., de Juan, L., Mateos, A., & Domínguez, L. (2004). Spoligotyping profile change caused by deletion of a direct variable repeat in a Mycobacterium tuberculosis isogenic laboratory strain. Journal of clinical microbiology, 42(11), 5388–5391. https://doi.org/10.1128/JCM.42.11.5388-5391.2004
Abstract
Spoligotyping is a major tool for molecular typing of Mycobacterium tuberculosis complex organisms. For epidemiological purposes, strains are considered clonal only when their spoligotyping patterns are identical. We report a change in the spoligotyping profiles of truly isogenic strains (a clinical isolate and a subculture derived in the laboratory) caused by deletion of a direct variable repeat. Without the information about the relationship between them, a link between these strains would have gone unnoticed. Evolutionary events should be taken into account in the interpretation of spoligotyping results and in the design of databases.
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Autor de correspondencia: Alicia Aranaz;
2004, American Society for Microbiology. All Rights Reserved.
Financiación: Ramon y Cajal Program (Spanish Ministry of Science and Technology).Pproject AGL 2001-2029 of the Spanish Ministry of Science and Technology and by the Spanish Ministry of Agriculture, Fisheries and Food (MAPA).