Magnetoencephalographic parietal δ dipole density in mild cognitive impairment: Preliminary results of a method to estimate the risk of developing Alzheimer disease

No Thumbnail Available
Full text at PDC
Publication Date
Advisors (or tutors)
Journal Title
Journal ISSN
Volume Title
American Medical Association
Google Scholar
Research Projects
Organizational Units
Journal Issue
Background: Subjects with mild cognitive impairment (MCI) are at a higher risk of experiencing Alzheimer disease (AD). Magnetoencephalographic temporoparietal dipole densities of low-frequency activity are good predictors of individuals' cognitive status, and might be a useful tool to investigate the conversion from MCI to AD. Objective: To investigate the role of low-frequency dipole densities as predictors of the risk of developing AD. Design: Whole-head magnetoencephalographic recordings were obtained from 19 probable AD patients, 17 MCI patients, and 17 healthy control subjects. The generators of focal magnetic slow waves were located using a single moving dipole model. Results: Left parietal δ dipole density permitted a reliable classification of AD and MCI patients. The MCI patients were divided into 2 groups based on the median left parietal δ dipole density, and were followed up for 2 years. The estimated relative risk of conversion to AD was increased by 350% in those MCI patients with high left parietal δ dipole density scores. Conclusions: Results confirmed the important role of parietal δ dipole density in the evaluation of AD and MCI. A magnetoencephalographic-based assessment of AD and MCI patients might be considered a useful clinical test in the near future.