(Ph3P)AuCl-catalyzed homocoupling of arylboronic acids under benchtop conditions: Synthesis of biphenyls

Roscales García, Silvia; Sánchez-Sancho, Francisco; García Csaky, Aurelio

(Ph3P)AuCl-catalyzed homocoupling of arylboronic acids under benchtop conditions: Synthesis of biphenyls

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Official URL

https://doi.org/10.1016/j.mcat.2023.113281

Publication date

2023

Authors

Roscales García, Silvia

Sánchez-Sancho, Francisco

García Csaky, Aurelio

Publisher

Elsevier

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URI

https://hdl.handle.net/20.500.14352/105128

Citation

Silvia Roscales, Francisco Sánchez-Sancho, Aurelio G. Csáky, (Ph3P)AuCl-catalyzed homocoupling of arylboronic acids under benchtop conditions: Synthesis of biphenyls, Molecular Catalysis, Volume 547, 2023, 113281, ISSN 2468-8231, https://doi.org/10.1016/j.mcat.2023.113281. (https://www.sciencedirect.com/science/article/pii/S2468823123003656)

Abstract

(Ph3P)AuCl was discovered to be a powerful catalyst in the homocoupling of arylboronic acids and potassium aryltrifluoroborates for the synthesis of symmetrical biaryls. The reactions take place under benchtop reaction conditions in 96% EtOH at temperatures between rt and 50 °C with no exclusion of air or humidity, in the presence of F-TEDA (Selectfluor™) as an oxidant. The procedure is very functional group tolerant, and affords the corresponding biaryls in high yields with large substrate scope (26 examples).