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NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases

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dc.contributor.authorCores Esperón, Ángel
dc.contributor.authorPiquero Martí, Marta
dc.contributor.authorVillacampa Sanz, Mercedes
dc.contributor.authorLeón Martínez, Rafael
dc.contributor.authorMenéndez Ramos, José Carlos
dc.date.accessioned2023-06-17T09:12:10Z
dc.date.available2023-06-17T09:12:10Z
dc.date.issued2020-06-14
dc.description.abstractNRF2 acts by controlling gene expression, being the master regulator of the Phase II antioxidant response, and also being key to the control of neuroinflammation. NRF2 activity is regulated at several levels, including protein degradation by the proteasome, transcription, and post-transcription. The purpose of this review is to offer a concise and critical overview of the main mechanisms of NRF2 regulation and their actual or potential use as targets for the treatment of neurodegenerative diseases.
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia e Innovación (MICINN)
dc.description.sponsorshipMinisterio de Economía y Competitividad (MINECO)
dc.description.sponsorshipComunidad de Madrid
dc.description.sponsorshipInstituto de Salud Carlos III (ISCIII)/FEDER
dc.description.sponsorshipInstituto de Salud Carlos III
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/67546
dc.identifier.doi10.3390/biom10060904
dc.identifier.issn2218-273X
dc.identifier.officialurlhttps://doi.org/10.3390/biom10060904
dc.identifier.relatedurlhttps://www.mdpi.com/2218-273X/10/6/904
dc.identifier.urihttps://hdl.handle.net/20.500.14352/8385
dc.issue.number6
dc.journal.titleBiomolecules
dc.language.isoeng
dc.page.initial904
dc.publisherMDPI
dc.relation.projectID(RTI2018-097662-B-I00; FPU15/03608)
dc.relation.projectIDBES-2016-076410P
dc.relation.projectIDNRF24AD-CM (B2017/BMD-3827); ELA-MADRID-CM (B2017/BMD-3813)
dc.relation.projectIDMiguel Servet II Program (CP16/00014)
dc.relation.projectID(grant PI17/01700)
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.keywordNRF2–ARE pathway
dc.subject.keywordneurodegenerative diseases
dc.subject.keywordoxidative stress
dc.subject.keywordKEAP1
dc.subject.keywordNRF2 regulation
dc.subject.ucmNeurociencias (Farmacia)
dc.subject.unesco2490 Neurociencias
dc.titleNRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases
dc.typejournal article
dc.volume.number10
dspace.entity.typePublication
relation.isAuthorOfPublication31b4f55b-ee1a-4131-908a-00c388204b1a
relation.isAuthorOfPublicationefc5f0d1-2db6-43f7-b5fc-b23c349993a8
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relation.isAuthorOfPublication7093c6ce-e368-44f0-a993-8f7212cb1c2a
relation.isAuthorOfPublication4c8ca147-677d-4846-97b7-d4419662ff60
relation.isAuthorOfPublication.latestForDiscovery31b4f55b-ee1a-4131-908a-00c388204b1a

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