NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases

Cores Esperón, Ángel; Piquero Martí, Marta; Villacampa Sanz, Mercedes; León Martínez, Rafael; Menéndez Ramos, José Carlos

NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases

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biomolecules-10-00904-v2.pdf (10.03 MB)

Official URL

https://doi.org/10.3390/biom10060904

Publication date

2020

Authors

Cores Esperón, Ángel

Piquero Martí, Marta

Villacampa Sanz, Mercedes

León Martínez, Rafael

Menéndez Ramos, José Carlos

Publisher

MDPI

Citations

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URI

https://hdl.handle.net/20.500.14352/8385

Abstract

NRF2 acts by controlling gene expression, being the master regulator of the Phase II antioxidant response, and also being key to the control of neuroinflammation. NRF2 activity is regulated at several levels, including protein degradation by the proteasome, transcription, and post-transcription. The purpose of this review is to offer a concise and critical overview of the main mechanisms of NRF2 regulation and their actual or potential use as targets for the treatment of neurodegenerative diseases.