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Selective estrogen receptor modulators as brain therapeutic agents

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https://doi.org/10.1677/JME-10-0122

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2010

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BioScientifica
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https://hdl.handle.net/20.500.14352/95498

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Arevalo MA, Santos-Galindo M, Lagunas N, Azcoitia I, Garcia-Segura LM. Selective estrogen receptor modulators as brain therapeutic agents. J Mol Endocrinol. 2011 Jan 19;46(1):R1-9. doi: 10.1677/JME-10-0122. PMID: 21071476.

Abstract

Selective estrogen receptor modulators (SERMs), used for the treatment of breast cancer, osteoporosis, and menopausal symptoms, affect the nervous system. Some SERMs trigger neuroprotective mechanisms and reduce neural damage in different experimental models of neural trauma, brain inflammation, neurodegenerative diseases, cognitive impairment, and affective disorders. New SERMs with specific actions on neurons and glial cells may represent promising therapeutic tools for the brain.

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2490 Neurociencias

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