Uptake of nanoparticles by alveolar macrophages is triggered by surfactant protein A

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dc.contributor.authorRuge, Christian Arnold
dc.contributor.authorKirch, Julian
dc.contributor.authorCañadas Benito, Olga
dc.contributor.authorSchneider, Marc
dc.contributor.authorPérez Gil, Jesús
dc.contributor.authorSchaefer, Ulrich Friedrich
dc.contributor.authorCasals Carro, María Cristina
dc.contributor.authorLehr, Claus Michael
dc.date.accessioned2024-01-22T14:59:52Z
dc.date.available2024-01-22T14:59:52Z
dc.date.issued2011-12
dc.descriptionFrom the clinical editor: In this nano-toxicology study of inhaled nanoparticles, the authors investigated the effect of pulmonary surfactant protein A on the interaction between nanoparticles and alveolar macrophages utilizing magnetite nanoparticles coated with different polymers (starch, carboxymethyldextran, chitosan, poly-maleic-oleic acid, phosphatidylcholine). Cellular binding and uptake of nanoparticles increased for nanoparticles treated with SP-A, whereas albumin, the prevailing protein in plasma, led to a significant decrease.
dc.description.abstractUnderstanding the bio-nano interactions in the lungs upon the inhalation of nanoparticles is a major challenge in both pulmonary nanomedicine and nanotoxicology. To investigate the effect of pulmonary surfactant protein A (SP-A) on the interaction between nanoparticles and alveolar macrophages, we used magnetite nanoparticles (110-180 nm in diameter) coated with different polymers (starch, carboxymethyldextran, chitosan, poly-maleic-oleic acid, phosphatidylcholine). Cellular binding and uptake of nanoparticles by alveolar macrophages was increased for nanoparticles treated with SP-A, whereas albumin, the prevailing protein in plasma, led to a significant decrease. A significantly different adsorption pattern of SP-A, compared to albumin was found for these five different nanomaterials. This study provides evidence that after inhalation of nanoparticles, a different protein coating and thus different biological behavior may result compared to direct administration to the bloodstream
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Ciencias Biológicas
dc.description.facultyFac. de Ciencias Químicas
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationRuge CA, Kirch K, Cañadas O, Schneider M, Pérez-Gil J, Schaefer UF, Casals C, Lehr CM. Uptake of nanoparticles by alveolar macrophages is triggered by surfactant protein A. Nanomedicine: Nanotechnology, Biology and Medicine 2011 Dec;7:690-693
dc.identifier.doi10.1016/j.nano.2011.07.009
dc.identifier.issn1549-9634
dc.identifier.officialurlhttps://www.sciencedirect.com/science/article/pii/S1549963411002863?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/20.500.14352/94434
dc.issue.number6
dc.journal.titleNanomedicine: Nanotechnology, Biology and Medicine
dc.language.isoeng
dc.page.final693
dc.page.initial690
dc.publisherElsevier
dc.rights.accessRightsrestricted access
dc.subject.cdu577.112
dc.subject.cdu616.2
dc.subject.cdu615.4
dc.subject.keywordSP-A
dc.subject.keywordProtein adsorption
dc.subject.keywordMacrophage clearance
dc.subject.ucmBioquímica (Biología)
dc.subject.ucmBiología molecular (Química)
dc.subject.ucmFarmacología (Medicina)
dc.subject.unesco2302.21 Biología Molecular
dc.subject.unesco2403 Bioquímica
dc.subject.unesco2302.22 Farmacología Molecular
dc.titleUptake of nanoparticles by alveolar macrophages is triggered by surfactant protein A
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number7
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery25a89a2f-a381-4f15-9a6b-59430ee96a63
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