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Assembly of glycoamino acid building blocks: a new strategy for the straightforward synthesis of heparan sulfate mimics

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dc.contributor.advisorFernández-Mayoralas, Alfonso
dc.contributor.authorRevuelta, Julia
dc.contributor.authorFuentes, Roberto
dc.contributor.authorLagartera, Laura
dc.contributor.authorHernáiz Gómez-Degano, María Josefa
dc.contributor.authorBastida, Agatha
dc.contributor.authorGarcía-Junceda, Eduardo
dc.contributor.authorFernández-Mayoralas, Alfonso
dc.date.accessioned2024-01-29T09:23:01Z
dc.date.available2024-01-29T09:23:01Z
dc.date.issued2018
dc.description.abstractA new strategy that enables a modular straightforward synthesis of heparan sulfate oligosaccharide mimics by the assembly of simple glycoamino acid building blocks is described. The coupling between units is readily carried out by an amidation reaction. Several glycoamino acid oligomers were prepared and their interaction with the FGF2 protein was analyzed.
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía y Competitividad (España)
dc.description.statuspub
dc.identifier.citationRevuelta J, Fuentes R, Lagartera L, Hernáiz MJ, Bastida A, García-Junceda E, et al. Assembly of glycoamino acid building blocks: a new strategy for the straightforward synthesis of heparan sulfate mimics. Chem Commun 2018;54:13455–8. https://doi.org/10.1039/C8CC08067D.
dc.identifier.doi10.1039/c8cc08067d
dc.identifier.essn1364-548X
dc.identifier.issn1359-7345
dc.identifier.officialurlhttps://doi.org/10.1039/c8cc08067d
dc.identifier.urihttps://hdl.handle.net/20.500.14352/95778
dc.issue.number95
dc.journal.titleChemical Communications
dc.language.isoeng
dc.page.final13458
dc.page.initial13455
dc.publisherRoyal Society of Chemistry
dc.relation.projectIDinfo:eu-repo/grantAgreement/MAT2015-65184-C2-2-R
dc.relation.projectIDinfo:eu-repo/grantAgreement/CTQ2015-66206-C2-1-R
dc.rights.accessRightsrestricted access
dc.subject.keywordChemical Synthesis, Design, Glycosaminoglycans
dc.subject.ucmCiencias
dc.subject.unesco23 Química
dc.titleAssembly of glycoamino acid building blocks: a new strategy for the straightforward synthesis of heparan sulfate mimics
dc.title.alternativeInglés
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number54
dspace.entity.typePublication
relation.isAuthorOfPublication14a27ceb-3319-4354-aad7-6f334701a505
relation.isAuthorOfPublication.latestForDiscovery14a27ceb-3319-4354-aad7-6f334701a505

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