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Assembly of glycoamino acid building blocks: a new strategy for the straightforward synthesis of heparan sulfate mimics

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Assembly_of_glycoamino_acid.pdf (1.7 MB)

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https://doi.org/10.1039/c8cc08067d

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2018

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Royal Society of Chemistry
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https://hdl.handle.net/20.500.14352/95778

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Revuelta J, Fuentes R, Lagartera L, Hernáiz MJ, Bastida A, García-Junceda E, et al. Assembly of glycoamino acid building blocks: a new strategy for the straightforward synthesis of heparan sulfate mimics. Chem Commun 2018;54:13455–8. https://doi.org/10.1039/C8CC08067D.

Abstract

A new strategy that enables a modular straightforward synthesis of heparan sulfate oligosaccharide mimics by the assembly of simple glycoamino acid building blocks is described. The coupling between units is readily carried out by an amidation reaction. Several glycoamino acid oligomers were prepared and their interaction with the FGF2 protein was analyzed.

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Ciencias

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23 Química

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