Use of extracellular vesicles from lymphatic drainage as surrogate markers of melanoma progression and BRAF V600E mutation

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dc.contributor.authorGarcía Silva, Susana
dc.contributor.authorBenito Martín, Alberto
dc.contributor.authorSánchez Redondo, Sara
dc.contributor.authorHernández Barranco, Alberto
dc.contributor.authorXiménez Embún, Pilar
dc.contributor.authorNogues Vera, Laura
dc.contributor.authorMazariegos, Marina S.
dc.contributor.authorBrinkmann, Kay
dc.contributor.authorAmor López, Ana
dc.contributor.authorMeyer, Lisa
dc.contributor.authorRodríguez, Carlos
dc.contributor.authorGarcía Martín, Carmen
dc.contributor.authorBoskovic, Jasminka
dc.contributor.authorLetón, Rocío
dc.contributor.authorMontero, Cristina
dc.contributor.authorRobledo, Mercedes
dc.contributor.authorSantambrogio, Laura
dc.contributor.authorSue Brady, Mary
dc.contributor.authorSzumera Ciećkiewicz, Anna
dc.contributor.authorKalinowska, Iwona
dc.contributor.authorSkog, Johan
dc.contributor.authorNoerholm, Mikkel
dc.contributor.authorMuñoz, Javier
dc.contributor.authorOrtiz Romero, Pablo Luis
dc.contributor.authorRuano, Yolanda
dc.contributor.authorRodríguez Peralto, José Luis
dc.contributor.authorRutkowski, Piotr
dc.contributor.authorPeinado, Héctor
dc.date.accessioned2026-01-27T10:02:55Z
dc.date.available2026-01-27T10:02:55Z
dc.date.issued2019-04-11
dc.description.abstractLiquid biopsies from cancer patients have the potential to improve diagnosis and prognosis. The assessment of surrogate markers of tumor progression in circulating extracellular vesicles could be a powerful non-invasive approach in this setting.We have characterized extracellular vesicles purified from the lymphatic drainage also known as exudative seroma (ES) of stage III melanoma patients obtained after lymphadenectomy. Proteomic analysis showed that seroma-derived exosomes are enriched in proteins resembling melanoma progression. In addition, we found that the BRAFV600E mutation can be detected in ES-derived extracellular vesicles and its detection correlated with patients at risk of relapse.
dc.description.departmentDepto. de Medicina
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationGarcía-Silva S, Benito-Martín A, Sánchez-Redondo S, Hernández-Barranco A, Ximénez-Embún P, Nogués L, et al. Use of extracellular vesicles from lymphatic drainage as surrogate markers of melanoma progression and BRAF V600E mutation. Journal of Experimental Medicine 2019;216:1061–70. https://doi.org/10.1084/jem.20181522.
dc.identifier.doi10.1084/jem.20181522
dc.identifier.issn0022-1007
dc.identifier.issn1540-9538
dc.identifier.officialurlhttps://doi.org/10.1084/JEM.20181522
dc.identifier.relatedurlhttps://rupress.org/jem/article/216/5/1061/121010/Use-of-extracellular-vesicles-from-lymphatic
dc.identifier.urihttps://hdl.handle.net/20.500.14352/131088
dc.issue.number5
dc.journal.titleJournal of Experimental Medicine
dc.language.isoeng
dc.page.final1070
dc.page.initial1061
dc.publisherRockefeller University Press
dc.rights.accessRightsrestricted access
dc.subject.keywordHuman disease genetics
dc.subject.keywordSolid tumors
dc.subject.ucmOncología
dc.subject.ucmDermatología
dc.subject.unesco3201.06 Dermatología
dc.subject.unesco3207.13 Oncología
dc.titleUse of extracellular vesicles from lymphatic drainage as surrogate markers of melanoma progression and BRAF V600E mutation
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number216
dspace.entity.typePublication
relation.isAuthorOfPublicationd3c5478c-c1f9-4252-acac-eb147ed2407b
relation.isAuthorOfPublication5a551b8b-d045-4122-b403-31b7089040cd
relation.isAuthorOfPublication9a1b056b-ced8-48af-87ca-f5c7131d46e7
relation.isAuthorOfPublication.latestForDiscoveryd3c5478c-c1f9-4252-acac-eb147ed2407b

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