Use of extracellular vesicles from lymphatic drainage as surrogate markers of melanoma progression and BRAF V600E mutation
Loading...
Download
Official URL
Full text at PDC
Publication date
2019
Advisors (or tutors)
Editors
Journal Title
Journal ISSN
Volume Title
Publisher
Rockefeller University Press
Citations
Exportar
Citation
García-Silva S, Benito-Martín A, Sánchez-Redondo S, Hernández-Barranco A, Ximénez-Embún P, Nogués L, et al. Use of extracellular vesicles from lymphatic drainage as surrogate markers of melanoma progression and BRAF V600E mutation. Journal of Experimental Medicine 2019;216:1061–70. https://doi.org/10.1084/jem.20181522.
Abstract
Liquid biopsies from cancer patients have the potential to improve diagnosis and prognosis. The assessment of surrogate
markers of tumor progression in circulating extracellular vesicles could be a powerful non-invasive approach in this setting.We
have characterized extracellular vesicles purified from the lymphatic drainage also known as exudative seroma (ES) of stage
III melanoma patients obtained after lymphadenectomy. Proteomic analysis showed that seroma-derived exosomes are
enriched in proteins resembling melanoma progression. In addition, we found that the BRAFV600E mutation can be detected in
ES-derived extracellular vesicles and its detection correlated with patients at risk of relapse.