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High performance of the automated ADVIA Centaur Systems SARS-CoV-2 Antigen Assay in nasopharyngeal samples with high viral load

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dc.contributor.authorRíos Dueñas, Esther
dc.contributor.authorMedrano, Sara
dc.contributor.authorÁlvarez, Mar
dc.contributor.authorValderrama Conde, María José
dc.contributor.authorVallejo, Luis
dc.contributor.authorDelgado-Iribarren García-Campero, Albert
dc.contributor.authorCulebras López, Esther
dc.date.accessioned2025-09-03T12:04:46Z
dc.date.available2025-09-03T12:04:46Z
dc.date.issued2022-12-17
dc.descriptionThis study was supported by the Community of Madrid and the European Union, through the European Regional Development Fund (ERDF), supported as part of the Union’s response to the COVID-19 pandemic (PROYECTO REACT-EU INMUNOVACTER-CM).
dc.description.abstractADVIA Centaur SARS-CoV-2 Antigen (COV2Ag) Assay (Siemens Healthineers) was evaluated for SARS-CoV-2 detection. A total of 141 nasopharyngeal samples were analyzed by this technique and results were compared with those obtained by quantitative reverse-transcription polymerase chain reaction (RT-PCR). The overall sensitivity and specificity of the test were 68.70% and 70%, respectively. Regarding cycle threshold (Ct) values, the COV2Ag test showed a sensitivity of 93.75% and 100% for nasopharyngeal samples with Ct < 25 and < 20, respectively. ADVIA Centaur COV2Ag Assay is a useful, automated, and rapid technique for early SARS-CoV-2 diagnosis and isolation of the infected individuals, avoiding its transmission.
dc.description.departmentDepto. de Medicina
dc.description.departmentDepto. de Genética, Fisiología y Microbiología
dc.description.facultyFac. de Medicina
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.sponsorshipComunidad de Madrid
dc.description.sponsorshipEuropean Commission
dc.description.statuspub
dc.identifier.citationRíos, E., Medrano, S., Alvarez, M., Valderrama, M. J., Vallejo, L., Delgado-Iribarren, A., & Culebras, E. (2023). High performance of the automated ADVIA Centaur Systems SARS-CoV-2 Antigen Assay in nasopharyngeal samples with high viral load. International Microbiology, 26(3), 471-474. https://doi.org/10.1007/S10123-022-00311-3
dc.identifier.doi10.1007/s10123-022-00311-3
dc.identifier.essn1618-1905
dc.identifier.issn1139-6709
dc.identifier.officialurlhttps://doi.org/10.1007/s10123-022-00311-3
dc.identifier.relatedurlhttps://link.springer.com/article/10.1007/s10123-022-00311-3
dc.identifier.urihttps://hdl.handle.net/20.500.14352/123653
dc.issue.number3
dc.journal.titleInternational Microbiology
dc.language.isoeng
dc.page.final474
dc.page.initial471
dc.publisherSpringer Nature
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu579
dc.subject.cdu578.7
dc.subject.cdu578.834
dc.subject.cdu579.61
dc.subject.cdu616.98
dc.subject.keywordSARS-CoV-2
dc.subject.keywordRapid antigen test
dc.subject.keywordPCR
dc.subject.keywordSensitivity
dc.subject.keywordSpecifcity
dc.subject.ucmMicrobiología (Biología)
dc.subject.ucmMicrobiología médica
dc.subject.ucmEnfermedades infecciosas
dc.subject.unesco2414 Microbiología
dc.subject.unesco2420 Virología
dc.subject.unesco2420.08 Virus Respiratorios
dc.subject.unesco3205.05 Enfermedades Infecciosas
dc.titleHigh performance of the automated ADVIA Centaur Systems SARS-CoV-2 Antigen Assay in nasopharyngeal samples with high viral load
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number26
dspace.entity.typePublication
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