High performance of the automated ADVIA Centaur Systems SARS-CoV-2 Antigen Assay in nasopharyngeal samples with high viral load
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2022
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Springer Nature
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Ríos, E., Medrano, S., Alvarez, M., Valderrama, M. J., Vallejo, L., Delgado-Iribarren, A., & Culebras, E. (2023). High performance of the automated ADVIA Centaur Systems SARS-CoV-2 Antigen Assay in nasopharyngeal samples with high viral load. International Microbiology, 26(3), 471-474. https://doi.org/10.1007/S10123-022-00311-3
Abstract
ADVIA Centaur SARS-CoV-2 Antigen (COV2Ag) Assay (Siemens Healthineers) was evaluated for SARS-CoV-2 detection. A total of 141 nasopharyngeal samples were analyzed by this technique and results were compared with those obtained by quantitative reverse-transcription polymerase chain reaction (RT-PCR). The overall sensitivity and specificity of the test were 68.70% and 70%, respectively. Regarding cycle threshold (Ct) values, the COV2Ag test showed a sensitivity of 93.75% and 100% for nasopharyngeal samples with Ct < 25 and < 20, respectively. ADVIA Centaur COV2Ag Assay is a useful, automated, and rapid technique for early SARS-CoV-2 diagnosis and isolation of the infected individuals, avoiding its transmission.
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This study was supported by the Community of Madrid and the European Union, through the European Regional Development Fund (ERDF), supported as part of the Union’s response to the COVID-19 pandemic (PROYECTO REACT-EU INMUNOVACTER-CM).