Aviso: para depositar documentos, por favor, inicia sesión e identifícate con tu cuenta de correo institucional de la UCM con el botón MI CUENTA UCM. No emplees la opción AUTENTICACIÓN CON CONTRASEÑA
 

TRB3 links ER stress to autophagy in cannabinoid anti-tumoral action

Simple item page
dc.contributor.authorSalazar Roa, María
dc.contributor.authorCarracedo, Arkaitz
dc.contributor.authorSalanueva, Íñigo
dc.contributor.authorHernández Tiedra, Sonia
dc.contributor.authorEgia, Ainara
dc.contributor.authorLorente Pérez, María Del Mar
dc.contributor.authorVázquez, Patricia
dc.contributor.authorTorres, Sofia
dc.contributor.authorIovanna, Juan
dc.contributor.authorGuzmán Pastor, Manuel
dc.contributor.authorBoya, Patricia
dc.contributor.authorVelasco Díez, Guillermo
dc.date.accessioned2024-02-01T13:54:52Z
dc.date.available2024-02-01T13:54:52Z
dc.date.issued2009
dc.description.abstractΔ9-tetrahydrocannabinol (THC), the main active component of marijuana, is being investigated as a potential anti-tumoral agent. We find that THC stimulates an endoplasmic reticulum (ER) stress-related signaling pathway, which activates autophagy via inhibition of the Akt/mTORC1 axis. We also show that autophagy is upstream of apoptosis in cannabinoid-induced cancer cell death and that activation of this pathway is necessary for the anti-tumoral action of cannabinoids in vivo.
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationSalazar, M., Carracedo, A., Salanueva, Í. J., Hernández-Tiedra, S., Egia, A., Lorente, M., … Velasco, G. (2009). TRB3 links ER stress to autophagy in cannabinoid antitumoral action. Autophagy, 5(7), 1048–1049. https://doi.org/10.4161/auto.5.7.9508
dc.identifier.doi10.4161/auto.5.7.9508
dc.identifier.essn1554-8635
dc.identifier.issn1554-8627
dc.identifier.officialurlhttps://doi.org/10.4161/auto.5.7.9508
dc.identifier.urihttps://hdl.handle.net/20.500.14352/97786
dc.issue.number7
dc.journal.titleAutophagy
dc.language.isoeng
dc.page.final1049
dc.page.initial1048
dc.publisherTaylor & Francis
dc.rights.accessRightsrestricted access
dc.subject.keywordAutophagy
dc.subject.keywordCannabinoids
dc.subject.keywordTRB3
dc.subject.keywordmTOR
dc.subject.ucmBiología celular (Biología)
dc.subject.unesco2403 Bioquímica
dc.titleTRB3 links ER stress to autophagy in cannabinoid anti-tumoral action
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number5
dspace.entity.typePublication
relation.isAuthorOfPublication85418c2e-51eb-43c9-a82f-05a96903381f
relation.isAuthorOfPublication974345b1-6b30-49ae-9724-2e4714f80000
relation.isAuthorOfPublicationdb8f53b8-3d54-4c2f-a483-c307151c09df
relation.isAuthorOfPublication4a33b5e2-6540-4927-ab0d-bc37f5cd8b5b
relation.isAuthorOfPublication.latestForDiscovery85418c2e-51eb-43c9-a82f-05a96903381f

Download

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Autophagy_in_cannabinoid_antitumoral_action.pdf
Size:
881.68 KB
Format:
Adobe Portable Document Format
downoload Download

Collections

Artículos