TRB3 links ER stress to autophagy in cannabinoid anti-tumoral action
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2009
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Taylor & Francis
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Salazar, M., Carracedo, A., Salanueva, Í. J., Hernández-Tiedra, S., Egia, A., Lorente, M., … Velasco, G. (2009). TRB3 links ER stress to autophagy in cannabinoid antitumoral action. Autophagy, 5(7), 1048–1049. https://doi.org/10.4161/auto.5.7.9508
Abstract
Δ9-tetrahydrocannabinol (THC), the main active component of marijuana, is being investigated as a potential anti-tumoral agent. We find that THC stimulates an endoplasmic reticulum (ER) stress-related signaling pathway, which activates autophagy via inhibition of the Akt/mTORC1 axis. We also show that autophagy is upstream of apoptosis in cannabinoid-induced cancer cell death and that activation of this pathway is necessary for the anti-tumoral action of cannabinoids in vivo.