Person:
Rosales Conrado, Noelia

First Name

Noelia

Last Name

Rosales Conrado

URI

https://hdl.handle.net/20.500.14352/76222

Affiliation

Universidad Complutense de Madrid

Faculty / Institute

Ciencias Químicas

Department

Química Analítica

Area

Química Analítica

Identifiers

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Search Results

Now showing 1 - 10 of 37

Learning Principal Component Analysis by Using Data from Air Quality Networks
(Journal of Chemical Education, 2017) Pérez Arribas, Luis Vicente; León González, María Eugenia; Rosales Conrado, Noelia
With the final objective of using computational and chemometrics tools in the chemistry studies, this paper shows the methodology and interpretation of the Principal Component Analysis (PCA) using pollution data from different cities. This paper describes how students can obtain data on air quality and process such data for additional information related to the pollution sources, climate effects, and social aspects over pollution levels by using a powerful chemometrics tool such as principal component analysis (PCA). The paper could also be useful for students interested in environmental chemistry and pollution interpretation; this statistical method is a simple way to display visually as much as possible of the total variation of the data in a few dimensions, and it is an excellent tool for looking into the normal pollution patterns.
Project number: 81
Página web del grupo bilingüe de la Facultad de Educación para la enseñanza de las ciencias: elaboración, explotación y juicio crítico de los estudiantes de cara a la internacionalización de la docencia
(2017) Peña Martínez, Juan; Sánchez Gómez, Pedro; Rosales Conrado, Noelia; Fresno Galán, María; Acebrón Hernández, Ainhoa; Merino Catalina, Beatriz; Cabezas Martínez, Sara; Meléndez Pérez, Celia; Martínez Arevalo, Victoria; Lazaro Sánchez, Paula
Elaboración de una página web con material didáctico de Ciencias para el grupo bilingüe de Educación, que además sirve para ofrecer información para estudiantes que pudieran estar interesados en formar parte del grupo, incluyendo estudiantes extranjeros.
Neuroprotective Action of Multitarget 7-Aminophenanthridin-6(5H)-one Derivatives against Metal-Induced Cell Death and Oxidative Stress in SN56 Cells
(ACS Chemical Neuroscience, 2021) Moyano-Cires Ivanoff, Paula Viviana; Vicente Zurdo, David; Blázquez-Barbadillo, Cristina; Menéndez Ramos, José Carlos; González Matilla, Juan Francisco; Rosales Conrado, Noelia; Pino Sans, Javier Del
Neurodegenerative diseases have been associated with brain metal accumulation, which produces oxidative stress (OS), matrix metalloproteinases (MMPs) induction, and neuronal cell death. Several metals have been reported to downregulate both the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway and the antioxidant enzymes regulated by it, mediating OS induction and neurodegeneration. Among a recently discovered family of multitarget 7-amino-phenanthridin-6-one derivatives (APH) the most promising compounds were tested against metal-induced cell death and OS in SN56 cells. These compounds, designed to have chelating activity, are known to inhibit some MMPs and to present antioxidant and neuroprotective effects against hydrogen peroxide treatment to SN56 neuronal cells. However, the mechanisms that mediate this protective effect are not fully understood. The obtained results show that compounds APH1, APH2, APH3, APH4, and APH5 were only able to chelate iron and copper ions among all metals studied and that APH3, APH4, and APH5 were also able to chelate mercury ion. However, none of them was able to chelate zinc, cadmium, and aluminum, thus exhibiting selective chelating activity that can be partly responsible for their neuroprotective action. Otherwise, our results indicate that their antioxidant effect is mediated through induction of the Nrf2 pathway that leads to overexpression of antioxidant enzymes. Finally, these compounds exhibited neuroprotective effects, reversing partially or completely the cytotoxic effects induced by the metals studied depending on the compound used. APH4 was the most effective and safe compound.
Project number: 47
Integración de los enfoques AICLE y CTIM en las actividades experimentales del grupo bilingüe de la Facultad de Educación
(2019) Peña Martínez, Juan; Rosales Conrado, Noelia; Sánchez Gómez, Pedro; García Núñez, Iván; Herrero Ojalvo, Ignacio Gilberto
En el presente proyecto se han rediseñado las prácticas de Física del grupo bilingüe para que los estudiantes apliquen el doble enfoque Ciencia-Tecnología-Ingeniería-Matemáticas (CTIM) y Aprendizaje Integrado de Ciencias en Lengua Extranjera (AICLE). Asimismo, se ha recabado su valoración para futuros trabajos.
A combined analytical-chemometric approach for the in vitro determination of polyphenol bioaccessibility by simulated gastrointestinal digestion
(Analytical and Bioanalytical Chemistry, 2022) Gómez Mejía, Esther; Rosales Conrado, Noelia; León González, María Eugenia; Valverde de la Fuente, Alejandro; Madrid Albarrán, Yolanda
In this study, an integrated characterisation through polyphenol and cafeine content and antioxidant activity was combined with chemometric analysis to assess the efects of simulated in vitro gastrointestinal digestion on the bioaccessibility of these bioactive compounds from nine diferent tea infusions. Tea infusions were characterised based on total favonoids, total polyphenols and antioxidant activity, together with the determination of individual polyphenol content. Fourteen phenolic compounds, including phenolic acids, stilbenes and favonoids, were selected based on their reported bioactivity and high accessibility, attributed to their low molecular weight. Both polyphenols and cafeine were initially monitored in raw tea infusions and through the diferent digestion stages (salivary, gastric and duodenal) by capillary high performance liquid chromatography coupled to diode array detection (cHPLC-DAD) and/or HPLC coupled to a triple quadrupole mass analyser (HPLC–MS/MS). Multivariate analysis of the studied bioactives, using principal component analysis and cluster analysis, revealed that the decafeination process seems to increase the stability and concentration of the compounds evaluated during digestion. The greatest transformations occurred mainly in the gastric and duodenal stages, where low bioactivity indices (IVBA) were shown for resveratrol and cafeic acid (IVBA=0%). In contrast, the polyphenols gallic acid, chlorogenic acid and quercetin gave rise to their availability in white, green and oolong infusion teas (IVBA>90%). Furthermore, highly fermented black and pu-erh varieties could be designated as less bioaccessible environments in the duodenum with respect to the tested compounds.
Project number: 71
Diseño de un e-portfolio para la adquisición de competencias transversales en Educación para la Sostenibilidad usando las TIC
(2021) Peña Martínez, Juan; Fernández Lázaro, Gloria; Pérez López, Raquel; Ortiz Iniesta, María Jesús; Lara Caballero, Ana; Rosales Conrado, Noelia; Andrés Casado, Nuria
Diseño de un portafolio digital, incluido sistema de rúbrica, para integrar la Educación para la Sostenibilidad en la enseñanza-aprendizaje de las ciencias experimentales favoreciendo el empleo de las TIC y competencias como el razonamiento reflexivo.
Project number: PIMCD213/23-24
Seminario permanente sobre educación para la paz
(2024) Peña Martínez, Juan; Rosales Conrado, Noelia; Salcedo Megales, Damián; Gonzalo Llera, Carolina; Momobela Rosario, Felicitas Carlota; Parello, Mara Lourdes; Li, Minghui; Jia, Qian
Se ha creado un espacio universitario donde, gracias a destacados especialistas en paz, desarrollo, seguridad y educación transformadora, se han aportado enfoques y prácticas para afrontar los desafíos de la convivencia social e impulsar la cultura de la paz, todo ello muy necesario para la formación inicial de maestros y maestras. Por otro lado, se ha facilitado y experimentado una propuesta didáctica orientada a promover el dialogo y respeto mutuo en el ámbito de la Didáctica de la Química. Finalmente, se ha llevado a cabo un estudio exploratorio sobre la actitud de los futuros docentes (estudiantes de la Facultad de Educación - Centro de Formación del Profesorado de la Universidad Complutense de Madrid) hacia la paz y la guerra.
Clase invertida de espectroscopía: una experiencia en el marco de un Programa de Excelencia para Bachillerato
(Educación Química, 2020) Gómez Gómez, Beatriz; Peña Martínez, Juan; Rosales Conrado, Noelia
En el presente trabajo se describe una experiencia didáctica en un curso de Bachillerato, perteneciente al Programa de Excelencia, de un centro escolar de la Comunidad de Madrid (España). Mediante un modelo de clase invertida o flipped classroom (de su traducción en inglés), se abordaron los fundamentos relacionados con las técnicas de análisis espectroscópico y se realizaron actividades experimentales como la preparación de un espectroscopio “casero”. Tras la intervención, se llevó a cabo una encuesta de satisfacción para conocer la percepción de los estudiantes sobre las actividades realizadas y sobre el modelo de enseñanza-aprendizaje aplicado. Los alumnos han valorado positivamente la nueva metodología, si bien, su aplicación ha generado un cierto desconcierto que puede generar dudas a la hora de aplicar el enfoque de clase invertida a otras asignaturas.
A Comprehensive Analytical Review of Polyphenols: Evaluating Neuroprotection in Alzheimer’s Disease
(International Journal of Molecular Sciences, 2024) Vicente Zurdo, David; Gómez Mejía, Esther; Rosales Conrado, Noelia; León González, María Eugenia De
Alzheimer’s Disease (AD), a prevalent neurodegenerative disorder, is the primary cause of dementia. Despite significant advancements in neuroscience, a definitive cure or treatment for this debilitating disease remains elusive. A notable characteristic of AD is oxidative stress, which has been identified as a potential therapeutic target. Polyphenols, secondary metabolites of plant origin, have attracted attention due to their potent antioxidant properties. Epidemiological studies suggest a correlation between the consumption of polyphenol-rich foods and the prevention of chronic diseases, including neurodegenerative disorders, which underscores the potential of polyphenols as a therapeutic strategy in AD management. Hence, this comprehensive review focuses on the diverse roles of polyphenols in AD, with a particular emphasis on neuroprotective potential. Scopus, ScienceDirect, and Google Scholar were used as leading databases for study selection, from 2018 to late March 2024. Analytical chemistry serves as a crucial tool for characterizing polyphenols, with a nuanced exploration of their extraction methods from various sources, often employing chemometric techniques for a holistic interpretation of the advances in this field. Moreover, this review examines current in vitro and in vivo research, aiming to enhance the understanding of polyphenols’ role in AD, and providing valuable insights for forthcoming approaches in this context.
Effect of Storage and Drying Treatments on Antioxidant Activity and Phenolic Composition of Lemon and Clementine Peel Extracts
(Molecules, 2023) Gómez Mejía, Esther; Sacristán Navarro, Iván; Rosales Conrado, Noelia; León González, María Eugenia De; Madrid Albarrán, María Yolanda
Obtaining polyphenols from horticultural waste is an emerging trend that enables the valorization of resources and the recovery of value-added compounds. However, a pivotal point in the exploitation of these natural extracts is the assessment of their chemical stability. Hence, this study evaluates the effect of temperature storage (20 and −20 ◦C) and drying methods on the phenolic composition and antioxidant activity of clementine and lemon peel extracts, applying HPLC-DADMS, spectrophotometric methods, and chemometric tools. Vacuum-drying treatment at 60 ◦C proved to be rather suitable for retaining the highest antioxidant activity and the hesperidin, ferulic, and coumaric contents in clementine peel extracts. Lemon extracts showed an increase in phenolic acids after oven-drying at 40 ◦C, while hesperidin and rutin were sustained better at 60 ◦C. Hydroethanolic extracts stored for 90 days preserved antioxidant activity and showed an increase in the total phenolic and flavonoid contents in lemon peels, unlike in clementine peels. Additionally, more than 50% of the initial concentration was maintained up to 51 days, highlighting a half-life time of 71 days for hesperidin in lemon peels. Temperature was not significant in the preservation of the polyphenols evaluated, except for in rutin and gallic acid, thus, the extracts could be kept at 20 ◦C.