Advances in the discovery of heterocyclic-based drugs against Alzheimer’s disease
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Publication date
2023
Advisors (or tutors)
Editors
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor and Francis
Citation
Sánchez, Juan D, Alcántara, Andrés R, González, Juan F, Sánchez-Montero, José María.Advances in the discovery of heterocyclic-based drugs against Alzheimer’s disease, Expert Opinion on Drug Discovery, Noviembre 2023 18:12, 1413-28, DOI: 10.1080/17460441.2023.2264766
Abstract
Introduction
Alzheimer’s disease is a multifactorial neurodegenerative disorder characterized by beta-amyloid accumulation and tau protein hyperphosphorylation. The disease involves interconnected mechanisms, which can be clustered into two target-packs based on the affected proteins. Pack-1 focuses on beta-amyloid accumulation, oxidative stress, and metal homeostasis dysfunction, and Pack-2 involves tau protein, calcium homeostasis, and neuroinflammation. Against this background heterocyclic system, there is a powerful source of pharmacophores to develop effective small drugs to treat multifactorial diseases like Alzheimer’s.
Areas covered
This review highlights the most promising heterocyclic systems as potential hit candidates with multi-target capacity for the development of new drugs targeting Alzheimer’s disease. The selection of these heterocyclic systems was based on two crucial factors: their synthetic versatility and their well-documented biological properties of therapeutic potential in neurodegenerative diseases.
Expert opinion
The synthesis of small drugs against Alzheimer’s disease requires a multifactorial approach that targets the key pathological proteins. In this context, the utilization of heterocyclic systems, with well-established synthetic processes and facile functionalization, becomes a crucial element in the design phases. Furthermore, the selection of hit heterocyclic should be guided by a full understanding of their biological activities. Thus, the identification of promising heterocyclic scaffolds with known biological effects increases the potential to develop effective molecules against Alzheimer’s disease.
Description
Este artículo fue solicitado por encargo al autor sin costes adicionales basado en la experiencia del autor sobre el tema.