Human leucocyte antigen-C in B chronic lymphocytic leukaemia
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2006
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Wiley
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Montes‐Ares, Olga, et al. «Human Leucocyte antigen‐C in B Chronic Lymphocytic Leukaemia». British Journal of Haematology, vol. 135, n.o 4, noviembre de 2006, pp. 517-19. https://doi.org/10.1111/j.1365-2141.2006.06334.x.
Abstract
This study aimed at characterising the distribution of human leucocyte antigen (HLA)-C alleles in a large group of patients with B chronic lymphocytic leukaemia from Southeastern Spain. Ninety-eight adult patients and 194 geographically and ethnically matched controls were studied. HLA-C was determined by polymerase chain reaction sequence-specific primers (PCR-SSP) and PCR-sequence-specific oligonucleotides (SSO) methods. The HLA-Cw*16 allele frequency was found to be significantly increased amongst patients compared with controls in our population (27·6% vs. 12·4%, P = 0·0012, Pc = 0·016). HLA-C dimorphism was also analysed but no association was found.