Steroid pathway and oestrone sulphate production in canine inflammatory mammary carcinoma

Sánchez-Archidona, Ana R.; Jiménez Martínez, María De Los Ángeles; Pérez Alenza, María De Los Dolores; Silván Granado, Gema; Illera Del Portal, Juan Carlos; Peña Fernández, Laura Luisa; Dunner Boxberger, Helene Susana

Steroid pathway and oestrone sulphate production in canine inflammatory mammary carcinoma

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https://doi.org/10.1016/j.jsbmb.2007.03.014

Publication date

2007

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ELSEVIER SCI LTD

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https://hdl.handle.net/20.500.14352/96321

Citation

Sánchez-Archidona, Ana R., et al. «Steroid pathway and oestrone sulphate production in canine inflammatory mammary carcinoma». The Journal of Steroid Biochemistry and Molecular Biology, vol. 104, n.o 3, mayo de 2007, pp. 93-99. ScienceDirect, https://doi.org/10.1016/j.jsbmb.2007.03.014.

Abstract

Spontaneous canine mammary inflammatory carcinoma (IMC) shares epidemiologic, histopathologic and clinical characteristics with the inflammatory breast carcinoma (IBC) disease in humans. We have analysed the steroids levels in serum and in tissue homogenates of IMC, the expression of two of their receptors (androgen and β-estrogen) and of three enzymes included in the steroidogenesis pathway (aromatase (CYP19A1), steroid sulphatase (STS) and estrogen sulfotransferase (EST)) trying to explain the specific accumulation of steroids in IMC tissues generating deposits in the form of lipid droplets whose presence can be attributed to steroids secreted by IMC cells. According to our working hypothesis, oestrone sulphate would be the main component of these lipid droplets. The presence of these steroid deposits would contribute to the intense proliferation and invasive behaviour of IMC and IBC, although their involvement in angiogenesis is yet to be demonstrated.