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Development of Geometry-Controlled All-Orthogonal BODIPY Trimers for Photodynamic Therapy and Phototheragnosis

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https://doi.org/10.1021/acs.orglett.2c01169

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2022

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https://hdl.handle.net/20.500.14352/72062

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Prieto Castañeda, A., García Garrido, F., Díaz Norambuena, C. et al. «Development of Geometry-Controlled All-Orthogonal BODIPY Trimers for Photodynamic Therapy and Phototheragnosis». Organic Letters, vol. 24, n.o 20, mayo de 2022, pp. 3636-41. DOI.org (Crossref), https://doi.org/10.1021/acs.orglett.2c01169.

Abstract

We have established an easy synthetic protocol for selectively developing all-orthogonal BODIPY trimers with unprecedented geometries on the basis of selecting methyl oxidation versus electrophilic formylation of key dimeric precursors. Photophysical characterization together with biological assays unraveled the most suitable BODIPY−BODIPY geometrical arrangements within the trimer, forcing them to serve as molecular platforms for the development of new, advanced heavy-atom-free photosensitizers for photodynamic therapy and phototheragnosis.

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CRUE-CSIC (Acuerdos Transformativos 2022)

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Química orgánica (Química)

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2306 Química Orgánica

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