An enzyme-controlled mesoporous nanomachine for triple-responsive delivery
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2022
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The Royal Society of Chemistry
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Mayol, B., Dato, V., Rodriguez, M., Lucena, E., Villalonga, A., Díez, P., Jimenez-Falcao, S., Sancenón, F., Sánchez, A., Vilela, D., Martínez-Ruíz, P., Martinez-Mañez, R., Villalonga, R. (2022). An enzyme-controlled mesoporous nanomachine for triple-responsive delivery. Journal of Materials Chemistry B, 10: 6983-6990
Abstract
The construction of a novel enzyme-controlled nanomachine with multiple release mechanisms for oncommand delivery is described. This nanodevice was assembled by modifying mesoporous silica nanoparticles with 2-(benzo[d]thiazol-2-yl)phenyl 4-aminobenzoate moieties, and further capped with b-cyclodextrin-modified glucose oxidase neoglycoenzyme. The device released the encapsulated payload in the presence of H2O2 and acidic media. The use of glucose as an input chemical signal also triggered cargo release through the enzymatic production of gluconic acid and hydrogen peroxide, and the subsequent disruption of the gating mechanism at the mesoporous surface. The nanodevice was successfully employed for the enzyme-controlled release of doxorubicin in HeLa cancer cells.
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Financial support from the Spanish Ministry of Economy and Competitiveness (projects CTQ2017-87954-P, PID2021-125723NBI00, MAT2015-64139-C4-1 and RTI2018-100910-B-C41) is gratefully acknowledged. The authors also thank the Generalitat Valencia (Project PROMETEO/2018/024) for support.