Combination of bioanalytical approaches and quantitative proteomics for the elucidation of the toxicity mechanisms associated to TiO2 nanoparticles exposure in human keratinocytes

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dc.contributor.authorMontalvo Quirós, Sandra
dc.contributor.authorLuque García, José Luis
dc.date.accessioned2024-07-08T17:15:41Z
dc.date.available2024-07-08T17:15:41Z
dc.date.issued2019-03-27
dc.description.abstractTitanium dioxide nanoparticles (TiO2-NPs) are being used in several consumer products. The high refractive index of nano-scaled titanium dioxide particles allows them to protect from UV radiation, and so, they can be found as one of the main components of cosmetics and suncreens. Many studies have reported the potential toxicological effects associated to TiO2-NPs such as ROS generation, DNA damage, apoptosis and cell cycle arrest, among others. The continuous and systematic use of TiO2-NPs in cosmetic products requires a full comprehension of the risks involving their sustained contact with the human skin. Thus, it is important to evaluate not only the hazardous effects but to elucidate the biomolecular mechanisms involved in such effects. Based on this premises, we have evaluated the potential toxicity of TiO2-NPs using a human epithelial cell culture (HaCaT cells) as in-vitro model, together with different bioanalytical approaches and mass spectrometry-based quantitative proteomics, to gain a deeper insight into the molecular mechanisms of toxicity associated to TiO2-NPs exposure.
dc.description.departmentDepto. de Química Analítica
dc.description.facultyFac. de Ciencias Químicas
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationMontalvo-Quiros, S.; Luque-Garcia, J. L. Combination of bioanalytical approaches and quantitative proteomics for the elucidation of the toxicity mechanisms associated to TiO2 nanoparticles exposure in human keratinocytes. Food and Chemical Toxicology 2019, 127, 197-205 DOI:10.1016/j.fct.2019.03.036.
dc.identifier.doi10.1016/j.fct.2019.03.036
dc.identifier.issn0278-6915
dc.identifier.officialurlhttps://www.sciencedirect.com/science/article/pii/S0278691519301644?via%3Dihubhttps://doi.org/10.1016/j.fct.2019.03.036
dc.identifier.urihttps://hdl.handle.net/20.500.14352/105821
dc.journal.titleFood and Chemical Toxicology
dc.language.isoeng
dc.page.final205
dc.page.initial197
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsembargoed access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu544
dc.subject.keywordTiO2 nanoparticles
dc.subject.keywordToxicity mechanisms
dc.subject.keywordQuantitative proteomics
dc.subject.ucmQuímica analítica (Química)
dc.subject.unesco23 Química
dc.titleCombination of bioanalytical approaches and quantitative proteomics for the elucidation of the toxicity mechanisms associated to TiO2 nanoparticles exposure in human keratinocytes
dc.typejournal article
dc.volume.number127
dspace.entity.typePublication
relation.isAuthorOfPublication33755978-b21f-4d9c-b103-0bd6cced5047
relation.isAuthorOfPublication0e1bab4e-f0e9-4101-bfae-6f72a2d96be2
relation.isAuthorOfPublication.latestForDiscovery33755978-b21f-4d9c-b103-0bd6cced5047
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