Immune Reconstitution After In Utero Bone Marrow Transplantation in a Fetus With Severe Combined Immunodeficiency With Natural Killer Cells
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1999
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Elsevier Science
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Gil J, Porta F, Bartolomé J, Lafranchi A, Verardi R, Notarangelo LD, Carlo-Stella C, Rodríguez R, Rodríguez JJ, Gurbindo D, Cela E, Zucca A, Fernández-Cruz E, Ugazio AG. Immune reconstitution after in utero bone marrow transplantation in a fetus with severe combined immunodeficiency with natural killer cells. Transplant Proc. 1999 Sep;31(6):2581. doi: 10.1016/s0041-1345(99)00510-2. PMID: 10500727.
Abstract
BONE MARROW TRANSPLANTATION (BMT) is the elective therapy for severe combined immune deficiencies (SCID). In utero transplant (IUT) of CD341
cells from paternal bone marrow (BM) has recently allowed immunologic reconstitution in two fetuses affected with SCID without natural killer (NK) cells.1,2
We report here the first IUT of haploidentical, paternal BM–derived hematopoietic progenitor cells in a male fetus with T2B1NK1 SCID.