Serum biomarkers in uncontrolled no heart-beating donors may identify kidneys that will never work after transplantation

López Farre, Antonio José; Santos Sancho, Juana María; Modrego, Javier; Zamorano León, José Javier; Martín, Leyre; Sánchez Fructuoso, Ana Isabel; Rodríguez Sierra, Pablo; Herrero Calvo, José Antonio; Río Gallegos, Francisco José Del; Barrientos Alberto; Barrientos Guzmán, Alberto

Serum biomarkers in uncontrolled no heart-beating donors may identify kidneys that will never work after transplantation

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https://link.springer.com/article/10.1007/s40620-015-0203-3

Publication date

2016

Publisher

Springer

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URI

https://hdl.handle.net/20.500.14352/99309

Citation

López-Farré, A.J., Santos-Sancho, J.M., Modrego, J. et al. Serum biomarkers in uncontrolled no heart-beating donors may identify kidneys that will never work after transplantation. J Nephrol 29, 119–127 (2016). https://doi.org/10.1007/s40620-015-0203-3

Abstract

Background/aims Kidneys from uncontrolled non heart-beating donors achieve a good level of renal function after transplantation. However, a number of them will never function in the recipient. Our aim was to determine if serum biomarkers associated with platelet activity, inflammation and the nitric oxide system in uncontrolled non heart-beating donors may help to predict no renal function recovery after renal transplantation. Methods Serum levels of interleukin (IL)-6, IL-10, intercellular cell adhesion molecule-1 (ICAM-1), cyclic guanosine monophosphate (cGMP), nitrite + nitrate and platelet factor-4 (PF4) were measured using enzyme-linked immunosorbent assay (ELISA) kits in 88 uncontrolled non heart-beating donors divided according to the renal functionality achieved in the recipients into functional (n = 76) and non functional (n = 12). Results Kidneys from donors with higher IL-6 levels (>900 pg/ml) were functional after transplantation. Serum cGMP levels below 372.3 fmol/l were also associated with kidneys that recovered the renal function. However, serum levels of PF4 showed the best correlation with recovery of renal functional in the recipients since they were significantly lower in the donors whose kidneys functioned after transplantation. Conclusions Serum PF4 levels in uncontrolled non heart-beating donors may be a good predictor for kidneys that never will reach functional recovery. Some serum cGMP, IL-6 and IL-10 levels may simply help identify kidneys that will function after transplantation.