Prognostic Value of Lymph Node Density in Lingual Squamous Cell Carcinoma
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2023
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MDPI
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Navarro Cuéllar, C.; Sada Urmeneta, Á.; Lorenzo Marcos, R.; Antúnez-Conde, R.; López López, A.; del Castillo Pardo de Vera, J.L.; González Martín-Moro, J.; Cebrián Carretero, J.L.; Alijo Serrano, F.; Dell’Aversana Orabona, G.; et al. Prognostic Value of Lymph Node Density in Lingual Squamous Cell Carcinoma. Appl. Sci. 2023, 13, 5611. https://doi.org/10.3390/ app13095611
Abstract
Lymph node density (LND)—the proportion of positive nodes among the total number of resected nodes—has emerged as a reliable prognostic factor in solid tumors. This study aims to assess the importance of LND in lingual squamous cell carcinoma (LSCC) and its prognostic involvement. A retrospective longitudinal study with 62 patients was performed. All patients were diagnosed with LSCC and submitted for tumor resection and neck dissection. Patients were stratified into low (<0.04) and high risk (≥0.04) based on LND. We analyzed the impact of LND on overall survival (OS) and disease-free survival (DFS), as well as the relationship between LND and the pathological staging, the involvement of positive margins, depth of invasion (DOI) and perineural infiltration. This study provides a substantial relationship between lymph node density (LND), overall survival (OS) and disease-free survival (DFS) in lingual squamous cell carcinoma (LSCC). A statistically significant distribution was found between LND, perineural infiltration and pathological staging, whereas no association was found with the rest of the prognostic variables analyzed.