Epigenetics in the Eye: An Overview of the Most Relevant Ocular Diseases
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2017
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Frontiers Media
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Alkozi, H.A., Franco, ., Pintor Just, J. J. «Epigenetics in the Eye: An Overview of the Most Relevant Ocular Diseases». Frontiers in Genetics, vol. 8, octubre de 2017, p. 144. DOI.org (Crossref), https://doi.org/10.3389/fgene.2017.00144.
Abstract
Sight for mammals is one of the most appreciated senses. In humans there are several factors that contribute to the increment in all kind of eye diseases. This mini-review will focus on some diseases whose prevalence is steadily increasing year after year for non-genetic reasons, namely cataracts, dry eye, and glaucoma. Aging, diet, inflammation, drugs, oxidative stress, seasonal and circadian style-of-live changes are impacting on disease prevalence by epigenetics factors, defined as stable heritable traits that are not explained by changes in DNA sequence. The mini-review will concisely show the data showing epigenetics marks in these diseases and on how knowledge on the epigenetic alterations may guide therapeutic approaches to have a healthy eye.
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