Microfluidic fabrication of vesicles with hybrid lipid/nanoparticle bilayer membranes

Perrotton, Julie; Ahijado Guzmán, Rubén; Moleiro, Lara; Tinao, Berta; Guerrero Martínez, Andrés; Amstad, Esther; Monroy Muñoz, Francisco; Arriaga, Laura

Microfluidic fabrication of vesicles with hybrid lipid/nanoparticle bilayer membranes

Official URL

https://doi.org/10.1039/c8sm02050g

Publication date

2019

Authors

Perrotton, Julie

Ahijado Guzmán, Rubén

Moleiro, Lara

Tinao, Berta

Guerrero Martínez, Andrés

Amstad, Esther

Monroy Muñoz, Francisco

Arriaga, Laura

Publisher

Royal Society of Chemistry

Citations

Exportar

URI

https://hdl.handle.net/20.500.14352/93252

Citation

Perrotton, Julie, et al. «Microfluidic Fabrication of Vesicles with Hybrid Lipid/Nanoparticle Bilayer Membranes». Soft Matter, vol. 15, n.o 6, 2019, pp. 1388-95. https://doi.org/10.1039/C8SM02050G.

Abstract

Hybrid lipid/nanoparticle membranes are suitable model systems both to study the complex interactions between nanoparticles and biological membranes, and to demonstrate technological concepts in cellular sensing and drug delivery. Unfortunately, embedding nanoparticles into the bilayer membrane of lipid vesicles is challenging due to the poor control over the vesicle fabrication process of conventional methodologies and the fragility of the modified lipid bilayer assembly. Here, the utility of water-in-oil-in-water double emulsion drops with ultrathin oil shells as templates to form vesicles with hybrid lipid/nanoparticle membranes is reported.