Microfluidic fabrication of vesicles with hybrid lipid/nanoparticle bilayer membranes
Loading...
Official URL
Full text at PDC
Publication date
2019
Advisors (or tutors)
Editors
Journal Title
Journal ISSN
Volume Title
Publisher
Royal Society of Chemistry
Citation
Perrotton, Julie, et al. «Microfluidic Fabrication of Vesicles with Hybrid Lipid/Nanoparticle Bilayer Membranes». Soft Matter, vol. 15, n.o 6, 2019, pp. 1388-95. https://doi.org/10.1039/C8SM02050G.
Abstract
Hybrid lipid/nanoparticle membranes are suitable model systems both to study the complex interactions between nanoparticles and biological membranes, and to demonstrate technological concepts in cellular sensing and drug delivery. Unfortunately, embedding nanoparticles into the bilayer membrane of lipid vesicles is challenging due to the poor control over the vesicle fabrication process of conventional methodologies and the fragility of the modified lipid bilayer assembly. Here, the utility of water-in-oil-in-water double emulsion drops with ultrathin oil shells as templates to form vesicles with hybrid lipid/nanoparticle membranes is reported.