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Hypothalamic-pituitary-adrenal axis response in borderline personality disorder without post-traumatic features

Citation

Carrasco JL, Díaz-Marsá M, Pastrana JI, et al. Hypothalamic-pituitary-adrenal axis response in borderline personality disorder without post-traumatic features. British Journal of Psychiatry. 2007;190(4):357-358. doi:10.1192/bjp.bp.106.022590

Abstract

Hypothalamic–pituitary–adrenal (HPA) axis sensitivity was investigated in 32 non-medicated patients with borderline personality disorder without comorbid post-traumatic syndromes and in 18 normal individuals using a modified dexamethasone suppression test (0.25 mg). Enhanced cortisol suppression was found in the patients v. controls (P < 0.05) and the percentage of participant's with non-suppression was smaller in the patient (34%) than in the control group (89%) (P < 0.01). Baseline cortisol levels in the patients were also lower than in the controls (P < 0.05). The 0.25 mg dexamethasone suppression test reveals increased feedback inhibition of the HPA in borderline personality disorder.

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