Hypothalamic-pituitary-adrenal axis response in borderline personality disorder without post-traumatic features
Loading...
Official URL
Full text at PDC
Publication date
2018
Advisors (or tutors)
Editors
Journal Title
Journal ISSN
Volume Title
Publisher
Cambridge University Press
Citations
Exportar
Citation
Carrasco JL, Díaz-Marsá M, Pastrana JI, et al. Hypothalamic-pituitary-adrenal axis response in borderline personality disorder without post-traumatic features. British Journal of Psychiatry. 2007;190(4):357-358. doi:10.1192/bjp.bp.106.022590
Abstract
Hypothalamic–pituitary–adrenal (HPA) axis sensitivity was investigated in 32 non-medicated patients with borderline personality disorder without comorbid post-traumatic syndromes and in 18 normal individuals using a modified dexamethasone suppression test (0.25 mg). Enhanced cortisol suppression was found in the patients v. controls (P < 0.05) and the percentage of participant's with non-suppression was smaller in the patient (34%) than in the control group (89%) (P < 0.01). Baseline cortisol levels in the patients were also lower than in the controls (P < 0.05). The 0.25 mg dexamethasone suppression test reveals increased feedback inhibition of the HPA in borderline personality disorder.