p38alpha MAPK can positively or negatively regulate Rac-1 activity depending on the presence of serum

Zuluaga, Susana; Gutiérrez Uzquiza, Álvaro; Bragado, Paloma; Alvarez-Barrientos, Alberto; Benito De Las Heras, Manuel R.; Nebreda,  Angel R; Porras Gallo, María Almudena

p38alpha MAPK can positively or negatively regulate Rac-1 activity depending on the presence of serum

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FEBS Letters - 2007 - Zuluaga - p38 MAPK can positively or negatively regulate Rac‐1 activity depending on the presence of.pdf (889.2 KB)

Official URL

https://doi.org/10.1016/j.febslet.2007.06.078

Publication date

2007

Authors

Zuluaga, Susana

Gutiérrez Uzquiza, Álvaro

Bragado, Paloma

Alvarez-Barrientos, Alberto

Benito De Las Heras, Manuel R.

Nebreda, Angel R

Porras Gallo, María Almudena

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URI

https://hdl.handle.net/20.500.14352/92697

Citation

Fraguas-Sánchez AI, Fernández-Carballido A, Martin-Sabroso C, Torres-Suárez AI. Stability characteristics of cannabidiol for the design of pharmacological, biochemical and pharmaceutical studies. Journal of Chromatography B 2020;1150:122188. https://doi.org/10.1016/j.jchromb.2020.122188.

Abstract

The small GTP-ase Rac-1 can trigger p38 MAPK activation and, in turn, p38alpha can regulate signalling pathways that potentially impinge on Rac-1 activity. We have investigated the cross-talk between p38alpha and Rac-1 and found that p38alpha regulates the association between Rac-1 and caveolin-1 in serum-deprived cardiomyocytes. This interaction depends on cell attachment and correlates with higher levels of active Rac-1. Actin organization might regulate the formation of Rac-1-caveolin-1 complexes. In contrast, the Rac-1-caveolin-1 interaction is almost undetectable in the presence of serum, where Rac-1 activity is negatively regulated by p38alpha. Our results indicate that p38alpha can differentially contribute to Rac-1 activation depending on the presence of serum.