Palladium-catalyzed cocyclotrimerization of arynes with a pyramidalized alkene
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2018
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Royal Society of Chemistry
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Alonso, J. M.; Quiroga, S.; Codony, S.; Turcu, A. L.; Barniol-Xicota, M.; Pérez, D.; Guitián, E.; Vázquez, S.; Peña, D. Palladium-catalyzed cocyclotrimerization of arynes with a pyramidalized alkene. Chem. Commun. 2018, 54, 5996-5999 DOI:10.1039/C8CC03188F.
Abstract
A pyramidalized alkene and diverse arynes are generated in the presence of a Pd-catalyst to afford [2+2+2] cocycloaddition products.
The metal-catalyzed 2+2+2] cocycloaddition of arynes with pyramidalized alkenes is presented. The generation of a highly reactive pyramidalized alkene in the presence of a large excess of in situ-produced arynes led to the corresponding cocyclotrimerization (1 : 2)-adducts in good yields, establishing the first example of a palladium-based reaction of a pyramidalized alkene.