Nanocarbon-Based Glycoconjugates as Multivalent Inhibitors of Ebola Virus Infection

Rodríguez Pérez, Laura; Ramos-Soriano, Javier; Pérez Sánchez, Alfonso; Illescas Martínez, Beatriz María; Muñoz, Antonio; Luczkowiak, Joanna; Lasala, Fátima; Rojo, Javier; Delgado Vázquez, Rafael; Martín León, Nazario

Nanocarbon-Based Glycoconjugates as Multivalent Inhibitors of Ebola Virus Infection

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Official URL

https://doi.org/10.1021/jacs.8b03847

Publication date

2018

Publisher

American Chemical Society

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URI

https://hdl.handle.net/20.500.14352/92801

Citation

Rodríguez-Pérez, L.; Ramos-Soriano, J.; Pérez-Sánchez, A.; Illescas, B. M.; Muñoz, A.; Luczkowiak, J.; Lasala, F.; Rojo, J.; Delgado, R.; Martín, N. Nanocarbon-Based Glycoconjugates as Multivalent Inhibitors of Ebola Virus Infection. J. Am. Chem. Soc. 2018, 140, 9891-9898 DOI:10.1021/jacs.8b03847.

Abstract

SWCNTs, MWCNTs, and SWCNHs have been employed as virus-mimicking nanocarbon platforms for the multivalent presentation of carbohydrates in an artificial Ebola virus infection model assay. These carbon nanoforms have been chemically modified by the covalent attachment of glycodendrons and glycofullerenes using the CuAAC “click chemistry” approach. This modification dramatically increases the water solubility of these structurally different nanocarbons. Their efficiency in blocking DC-SIGN-mediated viral infection by an artificial Ebola virus has been tested in a cellular experimental assay, finding that glycoconjugates based on MWCNTs functionalized with glycofullerenes are potent inhibitors of viral infection.