Biomarcadores en líquido cefalorraquideo en perros con meningoencefalitis de origen desconocido. Valor pronóstico
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2018
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24/01/2018
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Universidad Complutense de Madrid
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Abstract
Las meningoencefalitis de origen desconocido son unas de las enfermedades inflamatorias del sistema nervioso central más frecuentes en perros. Los objetivos de este trabajo han consistido en identificar los factores que puedan tener alguna influencia en el pronóstico y supervivencia de perros con esta enfermedad, así como intentar establecer qué concentraciones de lactato, tanto sanguíneo como en líquido cefalorraquídeo, pueden ser determinantes en el pronóstico. Para ello, se ha realizado un estudio clínico prospectivo en 45 perros con esta patología y, como grupo control, 11 perros con epilepsia idiopática. Se ha determinado si existe relación entre la evolución de la enfermedad y la supervivencia con diferentes factores: raza, peso, sexo, edad, signos clínicos, hallazgos de resonancia magnética, análisis sanguíneo, análisis de líquido cefalorraquídeo y tratamientos recibidos previos y posteriores al diagnóstico. También se han estudiado los principales biomarcadores en líquido cefalorraquídeo: lactato y otros metabolitos analizados mediante espectroscopia por resonancia magnética nuclear realizada a través de la determinación del hidrógeno...
Meningoencephalitis of unknown origin (MUO) are one of the most common inflammatory diseases of the central nervous system in dogs. The aim of this study is to find factors related with prognosis and outcome in dogs with this disease, as well as to establish which lactate concentrations, both in blood and cerebrospinal fluid (CSF), can be determinant for prognosis. A prospective clinical study was carried out on 45 dogs with MUO. Eleven dogs with idiopathic epilepsy were included as control group. It has been determined whether there is a relationship between disease progression and outcome with different factors as breed , bodyweight, gender, age, clinical signs, magnetic resonance imaging findings, blood tests, cerebrospinal fluid analysis and treatments received before and after diagnosis. Main biomarkers in cerebrospinal fluid have also been studied, such as lactate and other metabolites determined by nuclear magnetic resonance spectroscopy with respect to hydrogen...
Meningoencephalitis of unknown origin (MUO) are one of the most common inflammatory diseases of the central nervous system in dogs. The aim of this study is to find factors related with prognosis and outcome in dogs with this disease, as well as to establish which lactate concentrations, both in blood and cerebrospinal fluid (CSF), can be determinant for prognosis. A prospective clinical study was carried out on 45 dogs with MUO. Eleven dogs with idiopathic epilepsy were included as control group. It has been determined whether there is a relationship between disease progression and outcome with different factors as breed , bodyweight, gender, age, clinical signs, magnetic resonance imaging findings, blood tests, cerebrospinal fluid analysis and treatments received before and after diagnosis. Main biomarkers in cerebrospinal fluid have also been studied, such as lactate and other metabolites determined by nuclear magnetic resonance spectroscopy with respect to hydrogen...
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Tesis de la Universidad Complutense de Madrid, Facultad de Veterinaria, Departamento de Medicina y Cirugía Animal, leída el 24-01-2018