Person:
Rosales Conrado, Noelia

First Name

Noelia

Last Name

Rosales Conrado

URI

https://hdl.handle.net/20.500.14352/76222

Affiliation

Universidad Complutense de Madrid

Faculty / Institute

Ciencias Químicas

Department

Química Analítica

Area

Química Analítica

Identifiers

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Search Results

Now showing 1 - 10 of 26

Determination of phenolic compounds in residual brewing yeast using matrix solid-phase dispersion extraction assisted by titanium dioxide nanoparticles
(Journal of Chromatography A, 2019) Gómez Mejía, Esther; Rosales Conrado, Noelia; León González, María Eugenia De; Madrid Albarrán, María Yolanda; ELSEVIER
A simple and efficient low-cost matrix solid-phase dispersion (MSPD) extraction based on TiO2nanopar-ticles (NPs) and diatomaceous earth has been developed for the recovery of phenolic compounds fromresidual brewing yeast. Experimental conditions for MSPD extraction were optimized by an experimen-tal design approach. A screening factorial design plus replicates at the center point, followed by surfaceresponse analysis were used. The simultaneous identification and quantification of eleven main nat-ural polyphenols: caffeic, chlorogenic, p-coumaric, 3,4-dihydroxibenzoic, trans-ferulic and gallic acids,kaempferol, myricetin, naringin, quercetin and rutin, was possible by combining MSPD and capillaryliquid chromatography couple to a diode array detection system (cLC-DAD) and liquid chromatogra-phy couple to a triple quadrupole analyzer (LC–MS/MS). Moreover, residual brewing yeast extracts wereevaluated in terms of DPPH (1,1-diphenyl–2 picrylhydrazyl) free radical scavenging activity. Polyphenol-nanoparticle interaction was studied by UV–vis spectroscopy and electron transmission microscopy(TEM), pointing out a stable interplay that assists phenolic isolation. The extracted polyphenol quan-tities were within the 3.2-1,500 g g−1range, and the high antioxidant activity estimated suggested thatdeveloped MSPD is a successful, simple, efficient and rapid method for the extraction and recovery of bioactive phenolic compounds, which promotes the reuse and re-evaluation of brewing yeast agri-foodby-products.
Extraction of polyphenols and synthesis of new activated carbon from spent coffee grounds
(Scientific Reports, 2019) Ramón-Gonçalves, Marina; Alcaraz, Lorena; Pérez-Ferreras, Susana; León González, María Eugenia De; Rosales Conrado, Noelia; López, Félix A.; Nature Research
A valorization process of spent coffee grounds (SCG) was studied. Thus, a two-stage process, the first stage of polyphenols extraction and synthesis of a carbonaceous precursor and a subsequent stage of obtaining activated carbon (AC) by means of a carbonization process from the precursor of the previous stage, was performed. The extraction was carried out with a hydro-alcoholic solution in a pressure reactor, modifying time, temperature and different mixtures EtOH:H2O. To optimize the polyphenols extraction, a two-level factorial experimental design with three replicates at the central point was used. The best results were obtained by using a temperature of 80 °C during 30 min with a mixture of EtOH:H2O 50:50 (v/v). Caffeine and chlorogenic acid were the most abundant compounds in the analysed extracts, ranging from 0.09 to 4.8 mg∙g−1 and 0.06 to 9.7 mg∙g−1, respectively. Similarly, an experimental design was realized in order to analyze the influence of different variables in the AC obtained process (reaction time, temperature and KOH:precursor ratio). The best results were 1 h, 850 °C, and a mixture of 2.5:1. The obtained activated carbons exhibit a great specific surface (between 1600 m2∙g−1 and 2330 m2∙g−1) with a microporous surface. Finally, the adsorption capacity of the activated carbons was evaluated by methylene blue adsorption.
Learning Principal Component Analysis by Using Data from Air Quality Networks
(Journal of Chemical Education, 2017) Pérez Arribas, Luis Vicente; León González, María Eugenia; Rosales Conrado, Noelia
With the final objective of using computational and chemometrics tools in the chemistry studies, this paper shows the methodology and interpretation of the Principal Component Analysis (PCA) using pollution data from different cities. This paper describes how students can obtain data on air quality and process such data for additional information related to the pollution sources, climate effects, and social aspects over pollution levels by using a powerful chemometrics tool such as principal component analysis (PCA). The paper could also be useful for students interested in environmental chemistry and pollution interpretation; this statistical method is a simple way to display visually as much as possible of the total variation of the data in a few dimensions, and it is an excellent tool for looking into the normal pollution patterns.
Project number: 81
Página web del grupo bilingüe de la Facultad de Educación para la enseñanza de las ciencias: elaboración, explotación y juicio crítico de los estudiantes de cara a la internacionalización de la docencia
(2017) Peña Martínez, Juan; Sánchez Gómez, Pedro; Rosales Conrado, Noelia; Fresno Galán, María; Acebrón Hernández, Ainhoa; Merino Catalina, Beatriz; Cabezas Martínez, Sara; Meléndez Pérez, Celia; Martínez Arevalo, Victoria; Lazaro Sánchez, Paula
Elaboración de una página web con material didáctico de Ciencias para el grupo bilingüe de Educación, que además sirve para ofrecer información para estudiantes que pudieran estar interesados en formar parte del grupo, incluyendo estudiantes extranjeros.
Neuroprotective Action of Multitarget 7-Aminophenanthridin-6(5H)-one Derivatives against Metal-Induced Cell Death and Oxidative Stress in SN56 Cells
(ACS Chemical Neuroscience, 2021) Moyano-Cires Ivanoff, Paula Viviana; Vicente Zurdo, David; Blázquez-Barbadillo, Cristina; Menéndez Ramos, José Carlos; González Matilla, Juan Francisco; Rosales Conrado, Noelia; Pino Sans, Javier Del
Neurodegenerative diseases have been associated with brain metal accumulation, which produces oxidative stress (OS), matrix metalloproteinases (MMPs) induction, and neuronal cell death. Several metals have been reported to downregulate both the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway and the antioxidant enzymes regulated by it, mediating OS induction and neurodegeneration. Among a recently discovered family of multitarget 7-amino-phenanthridin-6-one derivatives (APH) the most promising compounds were tested against metal-induced cell death and OS in SN56 cells. These compounds, designed to have chelating activity, are known to inhibit some MMPs and to present antioxidant and neuroprotective effects against hydrogen peroxide treatment to SN56 neuronal cells. However, the mechanisms that mediate this protective effect are not fully understood. The obtained results show that compounds APH1, APH2, APH3, APH4, and APH5 were only able to chelate iron and copper ions among all metals studied and that APH3, APH4, and APH5 were also able to chelate mercury ion. However, none of them was able to chelate zinc, cadmium, and aluminum, thus exhibiting selective chelating activity that can be partly responsible for their neuroprotective action. Otherwise, our results indicate that their antioxidant effect is mediated through induction of the Nrf2 pathway that leads to overexpression of antioxidant enzymes. Finally, these compounds exhibited neuroprotective effects, reversing partially or completely the cytotoxic effects induced by the metals studied depending on the compound used. APH4 was the most effective and safe compound.
Project number: 47
Integración de los enfoques AICLE y CTIM en las actividades experimentales del grupo bilingüe de la Facultad de Educación
(2019) Peña Martínez, Juan; Rosales Conrado, Noelia; Sánchez Gómez, Pedro; García Núñez, Iván; Herrero Ojalvo, Ignacio Gilberto
En el presente proyecto se han rediseñado las prácticas de Física del grupo bilingüe para que los estudiantes apliquen el doble enfoque Ciencia-Tecnología-Ingeniería-Matemáticas (CTIM) y Aprendizaje Integrado de Ciencias en Lengua Extranjera (AICLE). Asimismo, se ha recabado su valoración para futuros trabajos.
Project number: 151
Elaboración de material de apoyo para la evaluación individual de trabajos realizados en grupo en el Grado en Química
(2015) Rosales Conrado, Noelia; León González, María Eugenia; Pérez Arribas, Luis Vicente; Ávila Brande, David; Martínez Del Campo, Teresa; Luna Costales, Amparo
Diseño y la elaboración de plantillas que puedan servir de apoyo a la docencia de la Química y que permitan evaluar objetivamente los resultados del proceso de enseñanza/aprendizaje en las prácticas de laboratorio realizadas en grupo.
Project number: 71
Laboratorio virtual de Química para los futuros maestros de Educación Primaria
(2016) Peña Martínez, Juan; Muñoz Muñoz, Alberto; Rosales Conrado, Noelia; Díaz Perea, María del Rosario; García García, Eugenia; Arillo Aranda, María Ángeles; Martin Puig, Patricia
Elaboración de un conjunto de prácticas virtuales que se han adaptado específicamente como complemento y extensión a las prácticas presenciales de Química que se imparten en la Facultad de Educación para los alumnos de Grado de Maestro en Educación Primaria. Con el material desarrollado, a partir de un laboratorio virtual de acceso gratuito, del proyecto "ChemCollective", se trabajará la competencia científica del alumnado a partir de un modelo didáctico que está especialmente diseñado para que los alumnos se adapten a su propio ritmo de aprendizaje y se establecen las bases para incorporar en ulteriores proyectos técnicas de análisis de información para evaluar y adaptar la metodología de enseñanza de un modo más eficaz.
Project number: 71
Diseño de un e-portfolio para la adquisición de competencias transversales en Educación para la Sostenibilidad usando las TIC
(2021) Peña Martínez, Juan; Fernández Lázaro, Gloria; Pérez López, Raquel; Ortiz Iniesta, María Jesús; Lara Caballero, Ana; Rosales Conrado, Noelia; Andrés Casado, Nuria
Diseño de un portafolio digital, incluido sistema de rúbrica, para integrar la Educación para la Sostenibilidad en la enseñanza-aprendizaje de las ciencias experimentales favoreciendo el empleo de las TIC y competencias como el razonamiento reflexivo.
Clase invertida de espectroscopía: una experiencia en el marco de un Programa de Excelencia para Bachillerato
(Educación Química, 2020) Gómez Gómez, Beatriz; Peña Martínez, Juan; Rosales Conrado, Noelia
En el presente trabajo se describe una experiencia didáctica en un curso de Bachillerato, perteneciente al Programa de Excelencia, de un centro escolar de la Comunidad de Madrid (España). Mediante un modelo de clase invertida o flipped classroom (de su traducción en inglés), se abordaron los fundamentos relacionados con las técnicas de análisis espectroscópico y se realizaron actividades experimentales como la preparación de un espectroscopio “casero”. Tras la intervención, se llevó a cabo una encuesta de satisfacción para conocer la percepción de los estudiantes sobre las actividades realizadas y sobre el modelo de enseñanza-aprendizaje aplicado. Los alumnos han valorado positivamente la nueva metodología, si bien, su aplicación ha generado un cierto desconcierto que puede generar dudas a la hora de aplicar el enfoque de clase invertida a otras asignaturas.