Platinum and Gold Catalysis: à la Carte Hydroamination of Terminal Activated Allenes with Azoles

Alonso Gómez, José Miguel; Muñoz, María Paz

Platinum and Gold Catalysis: à la Carte Hydroamination of Terminal Activated Allenes with Azoles

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Platinum_and_Gold_Catalysis.pdf (1.08 MB)

Official URL

https://doi.org/10.1021/acs.orglett.9b02949

Publication date

2019

Authors

Alonso Gómez, José Miguel

Muñoz, María Paz

Publisher

American Chemical Society

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URI

https://hdl.handle.net/20.500.14352/92460

Citation

Alonso, José Miguel, y María Paz Muñoz. «Platinum and Gold Catalysis: À La Carte Hydroamination of Terminal Activated Allenes with Azoles». Organic Letters, vol. 21, n.o 18, septiembre de 2019, pp. 7639-44. https://doi.org/10.1021/acs.orglett.9b02949.

Abstract

Nucleophilic additions to allenes catalyzed by transition metals represent a powerful tool to obtain selective access to diverse structures with numerous applications. Reported here is a straightforward methodology to achieve selective addition of azoles to the proximal or distal carbon of activated allenes depending on the catalyst used, unravelling a gold–platinum bimetallic catalysis approach for the 1,3-double addition of azoles to activated allenes to give 1,3-bisazole derivatives, an important scaffold in medicinal and organometallic chemistry.