Medicinal plants and natural products as neuroprotective agents in age-related macular degeneration

Bosch-Morell, Francisco; Villagrasa Sebastián, Victoria; Ortega Hernández-Agero, María Teresa; Acero De Mesa, Nuria; Muñoz-Mingarro, María Dolores; González Rosende, Eugenia; Castillo García, Encarna; Sanhauja Santafé, María Amparo; Soriano Guarinos, Pilar; Martínez-Solís, Isabel

Medicinal plants and natural products as neuroprotective agents in age-related macular degeneration

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Official URL

https://doi.org/10.4103/1673-5374.284978

Publication date

2020

Authors

Bosch-Morell, Francisco

Villagrasa Sebastián, Victoria

Ortega Hernández-Agero, María Teresa

Acero De Mesa, Nuria

Muñoz-Mingarro, María Dolores

González Rosende, Eugenia

Castillo García, Encarna

Sanhauja Santafé, María Amparo

Soriano Guarinos, Pilar

Martínez-Solís, Isabel

Publisher

Wolters Kluwer – Medknow

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URI

https://hdl.handle.net/20.500.14352/100298

Citation

'Bosch-Morell F, Villagrasa V, Ortega T, Acero N, Muñoz-Mingarro D, González-Rosende ME, Castillo E, Sanahuja MA, Soriano P, Martínez-Solís I. Medicinal plants and natural products as neuroprotective agents in age-related macular degeneration. Neural Regen Res. 2020 Dec;15(12):2207-2216'

Abstract

The retina may suffer neurodegenerative damages, as other tissues of the central nervous system do, and serious eye diseases may develop. One of them is age-related macular degeneration, which causes progressive loss of vision due to retina degeneration. Treatment of age-related macular degeneration focuses on antioxidant agents and anti-vascular endothelial growth factor compounds, among others, that prevent/diminish oxidative stress and reduce neovascularisation respectively. The phytochemicals, medicinal plants and/or plant-diet supplements might be a useful adjunct in prevention or treatment of age-related macular degeneration owing to their antioxidant and anti-vascular endothelial growth factor properties. This review article presents the most investigated plants and natural products in relation to age-related macular degeneration, such as saffron, ginkgo, bilberry and blueberry, curcuma or turmeric, carotenoids, polyphenols, and vitamins C and E. This study provides up-to-date information on the effects, treatments, safety and efficiency of these phytotherapy products.