Characterization of Garvicin ML, a Novel Circular Bacteriocin Produced by Lactococcus garvieae DCC43, Isolated from Mallard Ducks (Anas platyrhynchos)
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2011
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American Society for Microbiology
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Borrero, J., Brede, D. A., Skaugen, M., Diep, D. B., Herranz, C., Nes, I. F., Cintas, L. M., & Hernández, P. E. (2011). Characterization of garvicin ML, a novel circular bacteriocin produced by lactococcus garvieae DCC43, isolated from mallard ducks (Anas platyrhynchos). Applied and Environmental Microbiology, 77(1), 369-373. https://doi.org/10.1128/AEM.01173-10
Abstract
Lactococcus garvieae DCC43 produces a bacteriocin, garvicin ML (GarML), with a molecular mass of 6,004.2 Da. Data from de novo amino acid sequencing by tandem mass spectrometry and nucleotide sequencing by reverse genetics suggested that the bacteriocin is synthesized as a 63-amino-acid precursor with a 3-amino-acid leader peptide that is removed by cleavage. Subsequently, a covalent linkage between the N and C termini forms the mature version of this novel 60-amino-acid circular bacteriocin.